The tRNAscan-SE Search Server was created and is maintained by Lowe Lab at UCSC.

Citations

If you use this web server to predict tRNAs, please cite:

Lowe, T.M. and Chan, P.P. (2016) tRNAscan-SE On-line: Search and Contextual Analysis of Transfer RNA Genes. Nucl. Acids Res. 44:W54-57.

Chan, P.P., Lin, B.Y., Mak, A.J., and Lowe, T.M. (2021) tRNAscan-SE 2.0: Improved Detection and Functional Classification of Transfer RNA Genes. Nucl. Acids Res. 49:9077–9096.

If you find this resource helpful and use it in your research, please help support its funding by writing a quick email to Todd (lowe@soe.ucsc.edu) describing how it has been useful to you. Letters like these help bolster the case for future funding. (many thanks! -Todd)

tRNAscan-SE employs

1. Infernal: the RNA covariance similarity search package (Nawrocki & Eddy, Bioinformatics 29: 2933-2935, 2013),
2. a modified, optimized version of tRNAscan v1.3 (Fichant & Burks, J. Mol. Biol. 220: 659-671, 1991),
3. a new implementation of a multistep weight matrix algorithm for identification of eukaryotic tRNA promoter regions (Pavesi et al., Nucl. Acids Res. 22: 1247-1256, 1994),
4. the RNA covariance analysis package Cove v.2.4.2 (Eddy & Durbin, Nucl. Acids Res. 22: 2079-2088, 1994)

Funding

This work is supported by a grant from the National Institutes of Health (HG006753-02).